Mice were randomly allocated into six groups, with 12 mice in each group. The study was conducted for a total of 21 days. Group I, the sham control group, received one ICV injection of 0.9% saline, in addition to oral administration of Tween 80 with 0.9% saline, daily for 21 consecutive days. Group II, the AD-model group, received one ICV injection of STZ (3 mg/kg) dissolved in 0.9% saline [27]. Groups III to VI received one ICV STZ injection (3 mg/kg), and group III was treated with simvastatin (20 mg/kg, p.o.) suspended in Tween 80 with 0.9% saline 5 h after STZ injection and then daily for a total of 21 doses [28]. Groups IV to VI were treated with PFT (100 mg, 300 mg, and 600 mg/kg, p.o., respectively) suspended in Tween 80 with 0.9% saline 5 h after STZ injection and then daily for a total of 21 doses (Figure 1) [29].

Experimental design.

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