We purchased BALB/c-nu/nu female mice from Charles River Laboratories. All of the mice were housed in groups of 3-5 per cage and maintained at 22°C under a 12:12 h light/dark cycle with free access to water and standard laboratory food (MF diet, Oriental Yeast Co., Tokyo, Japan). Animal experiments were conducted in accordance with institutional and NIH guidelines for the humane use of animals.

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