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Data are expressed as median (ranges) for quantitative variables, and number (%) for categorical variables. Continuous data were compared by Mann Whitney or Kruskal–Wallis test for more than two groups and categorical data by Fisher’s exact test as appropriate considering the value distribution. Event-free survival was defined as the time from the date of TA diagnosis and the date of first vascular complication, death (of any cause), or last follow-up. Survivals were estimated using the Kaplan–Meier method and compared using log-rank test. Factors associated with the time-to-event outcomes (vascular ischemic complications and relapses) were evaluated using Cox models, with estimation of hazards ratios and their 95% confidence interval. All tests were two-tailed and p < 0.05 was considered statistically significant. Statistical analyses involved using GraphPad Prism v7.00 for Windows (GraphPad Software, La Jolla, CA, USA) and R software.

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