The first orientation was made just after the laboratory conclusion when the treatment was started. The lesions in the affected area were treated topically, exclusively with two drops, twice a day of PE. Both patients were instructed to clean their nails with soap, water, and a brush daily and to polish the affected areas of the nails weekly.

The follow-up included monthly interviews besides nail samples collection being conducted 1 month and 4 months later aiming to evaluate the clinical and laboratory outcomes.

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