Analyses were performed using GraphPad Prism version 9 software (GraphPad Software, San Diego, CA, USA). The area under the curve (AUC) was calculated using trapezoid rule. A p-value of 0.05 was considered statistically significant. Survival curves were compared using the Gehan–Breslow–Wilcoxon test; other results were compared using t-tests or an ANOVA, as indicated.

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