Differences in the P300 ERP were assessed using a two-way repeated-measures analysis of variance (ANOVA) with group (β-lactolin, placebo) and time (week 0, week 6) as factors. Differences in the N400 ERP were assessed using three-way ANOVA with group, time, and condition (word, non-word) as factors. The simple effects were analyzed for any statistically significant difference using ANOVA. The statistical analyses were performed using JMP (SAS Institute Japan Ltd., Tokyo, Japan). Between- and within-group comparisons of neuropsychological tests were done using unpaired and paired t-test, respectively. This statistical analysis was performed using SAS 9.4 (SAS Institute Japan Ltd.). The statistical significance was set at p < 0.05.

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