We collected the data from 162 patients treated at the Oscar Lambret Center (Lille, France), retrospectively. We included all the cancer patients treated with prostate SBRT using a dedicated Cyberknife® VSI or Cyberknife® M6 between January 1, 2011 and March 1, 2020.

The patients were divided into two different population groups, with the first group comprising patients with an indication for SBRT as a treatment for localized prostate disease who had never received local treatment, and the second group comprising patients treated with SBRT for an intra-prostatic recurrence after the first radiation of the external beam radiation therapy (EBRT) type or brachytherapy. Hormone therapy was administered before or during irradiation. Prostate biopsy was systematic before treatment initiation in both groups. With regard to the group of patients receiving re-irradiation with SBRT, we enrolled primary patients treated for prostate adenocarcinoma or other pelvic neoplasia. There was no rectal preservation strategy using an endorectal balloon or gel spacer. An empty rectum was used as the half-full bladder preparation protocol.

In the context of the first irradiation using SBRT, the prescription dose was 36.25 Gy in five fractions for an isodose of 80%. The clinical target volume (CTV) included the entire prostate gland and the proximal part of the seminal vesicles from patients classified as the intermediate-risk group according to the D’Amico classification. The margins of the planning target volume (PTV) were 5 mm in all directions, except in the posterior direction which was 3 mm. During focal or whole gland re-irradiation, the prescription dose was 36 Gy in six fractions for a prescription dose of 80%. The PTV margin was 2 mm (9).

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