Measurement of motor function was performed using the Hanging Wire test as detailed previously [41]. Briefly, mice were placed on a cage wire lid, inverted 50 cm above padding and observed for up to 1 min. The amount of time until the mouse fell to the padding was recorded. All mice were trained to the procedure for 1 week prior to data acquisition (8 weeks of age). All tests were performed twice-weekly until the mice were no longer able to perform the test. In all cases, the operator was naïve to experimental code. Triplicate measurements were taken and mean value was recorded for each session and weekly means were calculated. Animals were given 30-s breaks between test replicates.

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