Control participants will receive passive adherence support consistent with standard of care for PrEP programmes delivered by public sector health clinics. Control participants will return monthly to collect medication refills, report and receive support for side effects, and conduct special study activities (i.e. specimen collection; Table Table22).

Study related events and time points

* A R30.00 (~$2.00) voucher will be provided after each “special” study visit where specimens are collected (i.e. M3, 6, 12, 18, and 24)

Monthly activities will include (1) attendance check-in, (2) adherence support session (intervention arms only), (3) clinical assessment, (4) medication dispensing, (5) study visit reminders, and (6) study pack and voucher. Each month, study staff will contact participants up to three times via SMS and phone calls as study visit reminders to support retention. More details about intervention and control arms is available in Table Table33.

Components of adherence interventions

*Study packs included sanitary pads, condoms, snack, and medication refill reminder card

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