The Community PrEP Study will enrol a cohort of 480 HIV-negative South African AGYW aged 16–25 years, incorporating multiple study designs to address our three main study aims (Table (Table1).1). Specifically, a cross-sectional, mixed-methods study design will be used to quantitatively measure and qualitatively assess the acceptability and feasibility of using CBCT platforms to identify HIV-uninfected AGYW and offer PrEP (Aim 1). A randomized controlled trial will evaluate a behavioural intervention aimed at supporting prevention-effective adherence to PrEP (Aim 2). Finally, we will perform micro-costing and mathematical modelling analyses to calculate the cost-effectiveness of our PrEP delivery platform and adherence support programmes (Aim 3). Community advisory boards (CABs) were established to facilitate community engagement and acceptance, elicit feedback on study design, conduct analysis, and ensure that community views and perspectives were appropriately incorporated in a collaborative manner.

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