The sample size of participants was calculated using a single proportion population formula with a 95% confidence level. We hypothesized that the prevalence of HLA-B*57:01 allele among black Africans is less than 1% with a 1% margin error. Considering a 10% nonresponse rate, the minimum number of participants per country was estimated at 418 and a minimum sample size was estimated at 1672 for the four countries participating to the study.

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