For stability studies, QC samples were prepared at the same concentration levels as the QC used in the accuracy and precision study. The stability of ceftaroline in plasma samples was evaluated after storage at −20 °C and −80 °C. Stability was also determined after three freeze–thaw cycles. Three samples from each QC were subjected to three freeze–thaw cycles and analyzed after the third cycle. Samples were thawed at room temperature.

Post-preparative stability, that is, the stability of ceftaroline in the processed samples, was evaluated by maintaining it immediately after preparation at 4 °C.

The stability of ceftaroline during sample processing was studied as well. QC samples were kept at room temperature for 2 h, then processed and analyzed using the chromatographic method.

Ceftaroline in the samples was considered stable when the concentration at each level was within ±15% of the nominal concentration.

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