The regulons from the transcriptional networks calculated from UROMOL data were used to derive differential enrichment scores in each cohort separately using the two-tail GSEA method (R package RTNsurvival). We discretized the activity scores into “active” and “repressed” status, aggregated the regulon status in all cohorts, and used Fisher’s exact tests to find the association of regulon status with each class. P-values were BH-adjusted.

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