Statistical analyses were performed by using the GraphPad Prism ( One or two-way ANOVA and Student's t-test methods were used to analyze the differences between groups. The data were represented as mean ± s.d., *P < 0.05, **P < 0.01, and ***P < 0.001 compared to control group; ## P < 0.01, and ### P < 0.001 compared to TE treated group.

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