This was a Phase I, dose- and schedule-finding study of capivasertib with multiple expansion cohorts that included evaluation of capivasertib with fulvestrant (NCT01226316). Results from the earlier parts of the study presenting the dose-finding, recommended Phase II dose and pharmacodynamic evaluation, as well as efficacy in patients with advanced solid tumors and those with activating PIK3CA30 or AKT1 mutations, have previously been reported14,16. The final part of this study enrolled PTEN-mutant ER+ MBC patients into two subcohorts: fulvestrant naive and fulvestrant pretreated (with a maximum of 24 patients per cohort).

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