The present study was carried out between April and May 2020. A total of 126 individuals attended in the COVID specialty unit at the Regional High Specialty Hospital (HRAEPY in the Spanish acronym) in Merida, Yucatan, localized in the southeast of Mexico. A sample of 38 hospitalized patients (28 men and 10 women) admitted at the COVID unit with SARS-CoV-2 infection confirmed by PCR, aged between 21 and 73 years were selected for this study. Hospitalized patients with COVID-19 were divided into severe or critical (patients that required mechanical ventilation, sedation and prolonged bed rest) [14]. The study was approved by the Ethics Committee of the HRAEPY (No. CONBIOETICA-31-CEI-002-20170731) in connection with a research project (Identification code: 2020-010).

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