The neurobehavioral findings of the mice were assessed using the open field test (OFT), elevated plus maze (EPM) and novel object recognition test (NORT). The behavioral tests were performed 1 day before drug administration or 4 days after surgery. Mice underwent additional follow-up behavioral test 30 min after drug administration or 5 days after surgery according to the treatment plan. All the neurobehavioral tests were automatically video recorded and analyzed with an image analyzing system (SMART v2.5.21 software and SMART video tracking system, Panlab Harvard Apparatus, Barcelona, Spain) by an assessor blinded to the treatment groups. The mice sequentially performed the OFT, EPM and NORT.

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