Data for graphing was processed with GraphPad Prism 8.0 software. Statistical analyses were performed using the SPSS 25.0 statistical software package. For the comparison of quantitative data between groups, the Student’s t-test is used. Differences in means were considered statistically significant at P < 0.05. Significance levels are: *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001; ns, not significant.

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