The overlapped genes (OGEs) of the compound-putative targets and disease targets were charted by the Venn tool. We inputted the OGEs into the STRING database ( with confidence scores ≥ 0.4 and the species limited to “Homo sapiens”, and exported protein–protein interaction (PPI) data. Analyzed the PPI data and constructed network by the Cytoscape 3.8.0 (, and the non-connection genes were removed. We use the Analyzer plugin to analyze the PPI network and get the degree, through taking the over a double median of degree to get the preliminary hub network45. Then, using the CytoNCA plugin to analyze the preliminary hub network to get network topological parameters: BC, CC, DC, LAC, NC and SC. We took the excess median of BC, CC, DC, LAC, NC, and SC to obtain hub network46. The MCODE application calculated the hub network to get the dense regions47. The genes in dense regions from MCODE is called key targets.

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