The primary objective of this study was to describe the discordance of hormone receptors (HR) and HER2 status between primary tumours and matched metastases, on samples collected within 6 months from MBC diagnosis, and before any progression.

Secondary objectives were to search for factors predicting for HR and HER2 discordances, to evaluate whether HR and HER2 discordance had a prognostic impact on overall survival, and finally, to evaluate the evolution of HR and HER2 discordance over time, after the first progression.

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