The study was approved by the ethical committee of the University of California San Francisco, protocol number 10-03111, Comitê de Ética em Pesquisa da Prefeitura de Porto Alegre (Plataforma Brasil) protocol number 1.103.654 and the Brazilian Research Ethics Commission (CONEP) protocol number 223.811. Samples were obtained after receipt of informed consent. Genomic DNA was extracted from saliva using standard techniques. Blood samples were collected using standard techniques and used for the generation of lymphoblastoid cell lines. Clinical data were obtained from a physician examination and review of medical records.

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