To identify candidate transcription factors that bind the CC element, we performed in silico motif searches using the MEME suite (Bailey et al., 2009) using the normal and mutated (c.331 C > G) sequences. Analysis of de novo and previously characterized position weight matrixes (PWM) was performed with HOMER (v3.12) (Heinz et al., 2010) using peak summit coordinates and flags -size −50,50 -len 6,8,10,12.

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