SCL compounds were systematically listed as ligands from published paper mining [26, 27], TCMID ( [28], SymMap ( [29], and TCMSP databases ( [30]. All compound structures from PubChem ( [31] were filtered by utilizing the “Lipinski rules” of the Molinspiration database ( [32]. In the field of drug discovery, the Lipinski rules were used to screen the compound database to eliminate molecules that were unsuitable for drug use, including n·OHNH ≤ 5, n·ON ≤ 10, MW ≤ 500, and miLogP ≤5. Compounds that met the Lipinski rules and others that did not but possessed good bioactivity were used in systems pharmacology and molecular docking [33, 34]. The 2D structures (.sdf format) of all compounds were generated by ChemBioOffice2014 [35].

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