2.1. Prediction of the Active Ingredients of Plantaginis Herba and Its Targets
This protocol is extracted from research article:
Network Pharmacology-Based Investigation of the Mechanism of Action of Plantaginis Herba in Hyperuricemia Treatment
Evid Based Complement Alternat Med, Apr 8, 2021; DOI: 10.1155/2021/5595384

The keyword “Plantaginis Herba” was searched in the Chinese medicine systems pharmacology database and analysis platform (TCMSP) (http://tcmspw.com/) and the Encyclopedia of Traditional Chinese Medicine (ETCM) database (http://www.tcmip.cn/ETCM/), and the retrieved results were screened based on the following parameters: oral bioavailability (OB) ≥ 30% and drug-likeness (DL) ≥ 0.18. Then, the existing literature was searched for studies involving the ingredients of Plantaginis Herba for hyperuricemia treatment. The molecular structures (SDF format) of the obtained ingredients were obtained from the PubChem database (https://pubchem.ncbi.nlm.nih.gov/), and potential targets were predicted using the Swiss TargetPrediction database (http://www.swisstargetprediction.ch/). The potential targets were subjected to gene normalization using the UniProt database (http://www.UniProt.org/). The active ingredients and corresponding targets of Plantaginis Herba were imported into Cytoscape 3.8.0 software to construct an active ingredient-target network for Plantaginis Herba.

Note: The content above has been extracted from a research article, so it may not display correctly.



Q&A
Please log in to submit your questions online.
Your question will be posted on the Bio-101 website. We will send your questions to the authors of this protocol and Bio-protocol community members who are experienced with this method. you will be informed using the email address associated with your Bio-protocol account.



We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.