Data were analyzed using the GraphPad Prism 5 statistics program (GraphPad Software Inc., San Diego, United States). Data were expressed as means ± standard deviation (S.D.). Statistically significant differences between groups for western blot analysis were measured by one-way analysis of variance (ANOVA) followed by post hoc Tukey's multiple comparison test (parametric data). Statistical analysis of survival curves was performed using the Kaplan-Meier with a Mantel-Cox (log-rank) test. P < 0.05 was considered statistically significant. All P values are demonstrated in the graphics.

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