2.9. Gene ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways enrichment for targets

To identify the function of gene signature in VIR and NVIR, GO and KEGG analysis was performed by R software. For analysis gene signature function, which included molecular function (MF), BP, cellular component. GO and KEGG pathway enrichment analysis was carried out by Cluster Profiler[11] package to expound promising signaling pathways correlated with the immune. The significant enrichment was considered as P-value < .05.

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