2.3. Data extraction and quality assessment
This protocol is extracted from research article:
Prognostic and clinicopathological significance of miR-638 in cancer patients
Medicine (Baltimore), Apr 16, 2021; DOI: 10.1097/MD.0000000000025441

Data extraction was conducted independently by 2 investigators from identified research in agreement with prescribed standards, during which disagreements were resolved by reaching a consensus on all contents. The extracted data elements mainly included the following information: author, publication year, country, cancer type, sample size, recruitment time, detection method, endpoints, HR obtain method, and NOS score. Additionally, clinical-pathological parameters, including age, gender, tumor size, tumor differentiation, lymph node metastasis, TNM stage, distant metastasis, portal vein invasion, and vascular invasion, were also extracted. When HRs and their 95% CIs were given in the articles, these data were extracted directly. If the prognosis was plotted as Kaplan–Meier survival curve, the data were digitized by the software Engauge Digitizer version 4.1 and calculated as described.[22,23] The Newcastle–Ottawa Scale (NOS) was used to assess the quality of included studies.[24] This method comprised 3 parameters of quality: selection (score: 0–4), comparability (score: 0–2), and outcome assessment (score: 0–3), with total scores ranging from 0 to 9. The study with total scores greater than 6 was considered high quality in the present meta-analysis.

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