Taiwan's National Health Insurance Administration (NHIA) set up the NHIRD based on the single-payer NHI program. This program was inaugurated on March 1, 1995 and provides coverage to over 99% of all residents in Taiwan. We accessed the Longitudinal Health Insurance Database (LHID), a component of the NHIRD, which includes 1,000,000 insurants randomly selected from the 2000 Registry for Beneficiaries. All medical claims included both inpatient and outpatient visits and medical treatment for each insurant from the start of 1996 to the end of 2012. To comply with the Personal Information Protection Act, the identification of each insurant in the LHID was re-coded. The study protocol was conducted according to the principles described in the Declaration of Helsinki and institutional review board/ethics committee approval was obtained by the Institutional Review Board of China Medical University Hospital, Taiwan.

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