We extracted data from the MIMIC-III database, which included more than 40,000 intensive care unit (ICU) patients treated in a variety of critical care units (medical, surgical, coronary care, and neonatal) at the Beth Israel Deaconess Medical Center (Boston, MA) from 2001 to 2012.[20,21] Our Access to the database was approved by the Institutional Review Boards of the Massachusetts Institute of Technology and Beth Israel Deaconess Medical Center after we completed the National Institute of Health's web-based course and passed the examination on Protecting Human Research Participants. Similar to the previous work,[2225] we extracted clinical data, including patient demographics, vital signs, laboratory test results, and other related parameters. To protect patient privacy, information regarding the included patients was hidden. One of the authors obtained access to this information and was responsible for data extraction (certification number: 6182750). The requirement for written informed consent was waived because of the retrospective nature of the study.

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