Incidence rates per 100,000 age-adjusted to the population evaluated in the study by the SEER∗Stat Software version 8.3.6. Kaplan–Meier analyses assessed overall survival (OS) after stratification according to marital status, age, histologic subtype, metastatic status, and treatment. The significant differences were assessed in a log-rank test. Univariate and multivariate cox hazard regression analysis were performed to determine independent predictors of OS. Only the significant variables from univariate analysis were enrolled in the multivariate analysis. All statistical tests were 2-sided with a level of significance set at P < .05. Statistical analysis was performed with SPSS Statistical Package version 20.0.

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