2.6. Assessment of risk of bias

The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) assessment tool will be used for conducting an appraisal of the studies’ methodological quality. Every selected study will be evaluated by 2 reviewers independently, a third one as a consulter. The GRADE evaluation system included bias risk; heterogeneity; indirectness; imprecision; publication bias. And each level of evidence is divided into “very ”, “low”, “moderate”, or “high” judgment.

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