As previous literature reports, the occurrence of NRP was over 30%.[5,6] We preliminarily found that Nicorandil could reduce the occurrence to 15%, and taking α = 5%, 1-β = 80% with a 2-sided test, 118 cases will be calculated in each group. Considering a potential dropout of 20% in the 30-day-follow-up, 280 cases will be needed in total.

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