In order to obtain directly or indirectly interacting proteins related to DEGs, the STRING version 11.0 database (https://string-db.org/) was used.[29] At the same time, the confidence score was set as >0.7 and species limited to “Homo sapiens.” Subsequently, the Cytoscape version 3.7.1 (http://www.cytoscape.org/) plug-in the molecular complex detection (MCODE) was used to identify the key modules from PPI network.[21] And modules with MCODE score >4.5 were presented.

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