Participants in the DT group were treated with a NOAC plus a P2Y12 inhibitor.

Participants in the TT group were treated with aspirin, a P2Y12 inhibitor and a vitamin K antagonist.

Major adverse cardiac events (MACEs)[10] were defined as a combination of all-cause death, myocardial infarction, stroke, and revascularization.

Stent thrombosis was defined according to the Academic Research Consortium (ARC).[11]

International Society on Thrombosis and Hemostasis (ISTH) major bleeding[12] has been defined as clinically overt bleeding that is associated with a fall in hemoglobin of 2 g/dl or more, or a transfusion of 2 or more units of packed red blood cells or whole blood or a critical site such as intraocular, intraspinal, intracerebral, pericardial, intra-articular, retroperitoneal, or a fatal outcome.

Thrombolysis in Myocardial Infarction (TIMI) major bleeding[12] has been defined as any symptomatic intracerebral hemorrhage, or clinically overt signs of hemorrhage including imaging, associated with a decrease in hemoglobin of equal to or more than 5 g/dl or an absolute decrease in hematocrit level of ≥15%.

TIMI minor bleeding[12] has been defined as any clinically overt sign of hemorrhage that is associated with a decrease in hemoglobin level of 3 to 5 g/dl or a fall in hematocrit of 9% to 15%.

The adverse cardiovascular outcomes and bleeding events which were reported in the original studies have been listed in Table Table11 and the outcomes which have been analyzed included:

The outcomes and follow-up which were reported in the original studies.


Myocardial infarction (MI);



Stent thrombosis;

Total major bleeding;

Total minor bleeding;

TIMI defined major bleeding;

TIMI defined minor bleeding;

Intracranial bleeding;

ISTH major bleeding.

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