Patients with sustained acute STEMI and suitable for PCI in hospital will be screened. Patients meeting the following criteria will be included:

aging from 18 to 85 years old;

diagnosis of acute STEMI within 12 hours;

total occlusion of the infarcted artery;

blood pressure less than 90/60 mm Hg.

Patients with left bundle-branch block, kidney dysfunction, and histories of myocardial infarction, PCI, coronary artery bypass grafting will be excluded. Before randomization, all patients or authorized persons will sign a written informed consent, and they can freely choose whether to continue the trial at any time.

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