Two independent reviewers will evaluate the risk of bias of the included randomized controlled trials on the basis of the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 by using Cochrane Collaboration's tool for assessing the risk of bias. The score consists of 7 items, including random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, selective reporting, and other bias. When evaluating the methodological quality of retrospective studies, the Methodological Index for Non-randomized Studies criteria will be used.

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