Study included in this review has to meet all of the following inclusion criteria in the PICOS order:

population: patients with CHF and COPD;

intervention group (group 1): routine treatment with trimetazidine and bisoprolol;

comparison group (group 2): routine treatment without trimetazidine and bisoprolol;

outcome measures: all-cause mortality and hospitalization for cardiac or/and respiratory causes; left ventricular structure and function; and functional scores;

study design: randomized controlled trial or observational study.

Biomechanical studies, in vitro studies, review articles, techniques, case reports, letters to the editor, and editorials are excluded.

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