Data were initially entered and analyzed using Meta Disc software version 1.4 for Windows.

The following measures of test accuracy were computed to assess the accuracy of 68Ga-PSMA-PET/CT and bone scan for the diagnosis of bone metastasis: SEN, SPE, +LR, -LR, and DOR. The SROC curves were pooled to evaluate the overall diagnostic performance. Chi Squared test was used for SEN and SPE heterogeneity test, and Cochran Q test was used for DOR, +LR, -LR. The heterogeneity of each index was divided into 3 categories. I2 < 50% indicates low heterogeneity, 75% > I2 ≥ 50% indicates medium heterogeneity, and I2 ≥ 75% indicates high heterogeneity. When I2 < 50%, evidence shows no significant heterogeneity, use fixed-effects model, On the contrary, the random effects (RE) model is adopted.[9]

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