The publications fulfilling the following criteria were included: an original study evaluating the association between IL-8-251 A/T polymorphism and the risk and/or mortality of sepsis; objects in each study were from the same epoch; including a case group of sepsis; including a control group; including precise sample size of IL-8-251 A/T polymorphism of case and control groups that could be directly extracted or calculated based on the information available.

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