Two researchers selected the quality assessment methods provided by Cochrane Handbook, including risk bias assessment form and Jadad modified scale. In case of disagreement, it will be decided by a third researcher. According to the methodology of randomized controlled trial, the following evaluation items will be adopted: random sequence generation, allocation concealment, blind methods, results data integrity, selective outcome reporting and other bias. As a result, the quality of evidence will be accepted as low risk, high risk, or ambiguous bias risk.

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