All authors will receive specific training at PRISMA-P before the implementation of the study. Review process will be independently conducted by 2 authors, using blinding to reduce bias. Disagreements will be resolved first by discussion and then by consulting a third author for arbitration. Endnote X7 will be used to manage and screen literature. RCTs that are duplicative and do not meet the eligibility criteria will be removed. Details of literature screening process is shown in Figure Figure11.

Flow diagram for study selection.

Then, Excel 2011 software will be used to extract relevant data. The relevant information that needs to be extracted is as follows:

basic information: title, the first author's name, year of publication;

study characteristics: interventions, course of treatment, duration;

subjects characteristics: sample size, gender, age, and underlying disease;

outcomes and specific adverse reactions.

When there is uncertain information in included studies, the final decision will be made through discussion among team members.

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