We will search the following databases (The retrieval time is from the establishment of each database to December 2020): PubMed, the Cochrane Library, Embase, Web of Science, China Biology Medicine (CBM), China National Knowledge infrastructure (CNKI), Wan Fang Data, the Chinese Science and Technology Periodical Database (VIP). The group of search words was a combination of human, inflammation and caloric restriction (or fasting or restriction caloric or low-calorie diet or intermittent fasting or hunger strike or time restricted feedings or fasting intermittent). Take PubMed as an example to list the retrieval strategy, which will be attached as Annex 1(https://www.kdocs.cn/l/so0GXtgkxWxD).

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