The data analysis of this study will be conducted through Review Manager Version 5.3 software. We will use OR and 95%CI to represent. If there are no findings of statistical heterogeneity, the fixed-effect model is adopted for data synthesis. If there is significant statistical heterogeneity, we will apply the random effect model. All participants will explore the possible causes from a clinical and methodological perspective and provide a descriptive or subgroup analysis.

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