The Hellenic Sepsis Study Group (HSSG) is collecting clinical data and biosamples from patients with sepsis since 2006 from 65 study sites across Greece (intensive care units, emergency departments and departments of internal medicine or surgery; www.sepsis.gr). The patients are enrolled after written consent provided by themselves or by their first-degree relatives (for patients unable to consent). The protocol is approved by the Ethics Committees of the participating hospitals.

Animal experiments were conducted in the unit of animals for medical scientific purposes of ΑΤΤΙΚΟΝ University General Hospital (Athens, Greece) according to EU Directive 2010/63/EU and to the Greek law 2015/2001, which incorporates the Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes of the Council of Europe (code of the facility EL 25BIO014, approval no. 1853/2015). All experiments were licensed from the Greek veterinary directorate under the protocol number 5591/19-10-2017.

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