All statistical data were summarized as the mean ± standard deviation (S.D). Student’s two tailed t test was used for pairwise comparisons, and one-way ANOVA with Bonferroni was used to test for multiple comparisons. Data were analyzed using Origin Pro 8.0 software (OriginLab, USA), and P values < 0.05 were considered significantly different. The numerical data used in all figures are included in S1 Data.

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