We systematically searched the MEDLINE & PubMed, EMBASE, and EBSCO databases using the following search terms: “inflammat*” and “breast”. The Medical Subject Heading term “inflammatory breast neoplasms” was applied and adapted for each database as necessary. The original protocol in PROSPERO was registered in 2018 and purposed to update the articles in the last 20 years [23]. Searches were limited to clinical trials during 1998–2020 (last search update was performed on July 15, 2020). The search strategy also included hand-searching the reference lists of relevant articles. To be included, studies had to be published in English. All searches were guided by an expert team from the Research Medical Library at The University of Texas MD Anderson Cancer Center. The search strategy for Ovid MEDLINE is provided in S1 Table.

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