To perform the comparison with the values of the EMA, the quotient of the daily doses (QDDD) was formed from Japanese and EMA values, as follows:

If the quotient gives a value of one, it means that the Japanese dose and the EMA dose are the same. Quotients that exceed the value of one mean that the Japanese dosages are higher and values below one indicate that they are lower. If there was no EMA value for an active ingredient, the antimicrobial agent was excluded from the comparison. The effects on the comparison of the number of active ingredients contained in the product and the administration route was examined.

The comparison of DDDjp and DDDvet was not made for antimicrobials for intramammary and intrauterine administration routes because DDDvet values for these antimicrobials were not available per kg per day. The EMA defines DDDvet values for these antimicrobials on one unit per teat, udder or animal basis [9].

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