For each eye, linear regression was performed to estimate the slope of MD over time using all VF data. Linear regression of MD, which quantifies the overall or generalized sensitivity loss (adjusted for age) averaged across the VF, has been shown to be superior to other global indices in detecting deterioration, particularly among patients undergoing more rapid progression [34]. Rapid progression was defined as worsening of MD by 1 dB/year or more in a given eye [6].

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