Statistical analyses were performed as previously indicated. 29 Coefficient of drug interaction (CDI) was calculated as: CDI = AB/(A × B). AB represents the percentage of viable cells remaining after the treatment with the combined drugs, while A and B represent the percentage of viable cells remaining after single treatments. CDI < 1 indicates a synergistic effect, CDI = 1 indicates an additive effect, CDI > 1 indicates antagonism.

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