Tumor response dynamics were assessed according to RECIST V.1.1 criteria.11 For the assessment of ETS and DoR, the longest diameters of the RECIST-defined target lesions were measured and summed for each assessment. Changes in the sum of the longest diameters of the RECIST-defined target lesions were expressed as a relative change from baseline. For ETS, the relative change from baseline at the first tumor assessment (week 8/9) was considered, whereas for DoR the relative change from baseline at the nadir was considered. Non-target lesions were not considered in the measurement of change in tumor size, as previously reported,12 but the worsening of non-target lesions and/or newly occurring lesions identified per se a RECIST-defined disease progression independently from a favorable dynamics of target lesions. All the images were centrally reviewed at the Fondazione IRCCS Istituto Nazionale dei Tumori by a dedicated radiologist blinded to the clinical outcome of the patients.

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